I also fully understand what is being replaced, why it is replaced and what replacement I want to the extent that I could manually install 200+ mods and it will be stable. It is probably as I have used NMM since Skyrim and I know every flaw/glitch and shortcut. ![]() A little like asking which is the best car as every model has it's ups and downs. It's just in my experience, I have had problems and spent an hour finding it when it takes me 2 minutes on others and likewise it is purely my opinion. )ĭon't get me wrong, I have used Vortex a lot and if it sounds like a criticism then to you and everyone I apologise sincerely. Therefore I won't start pointing out my ignorance by faulting flaws in it that don't exist. I've no idea on the NMM's state of current development if I'm being perfectly honest. Its means of literally overwriting (next mod overwrites the files of the last mod installed) was one of its worst features. At that point in time it was an absolutely terrible implementation of mod management. I threw NMM to the curb many moons ago, pre-Vortex, when it was all but useless to any but those who couldn't let go of the familiarity. MO2 is completely virtualized, your vanilla remains completely vanilla. ![]() The rest are load overhead, no more or less.Īs far as profiles and instances go, if that's your ultimate goal, you should be using MO2 for Fallout 4, not NMM or Vortex at all. Only the last one (in the case provided) will do anything. NMM lets you screw up, without warning, and load all of those plugins. Live Dismemberment off the top of my head if you want to try one) or you say no and enable the plugins you do want separately. Up to you, in Vortex you either say yes and disable the plugins you don't want (i.e. It doesn't give you a pick or choose list, no, but neither does NMM, or MO. Vortex lets you know there are multiple plugins and will enable them all (or none) depending on whether you answer yes/no to the "has multiple plugins, enable them all" question. Just like NMM (and MO/MO2, fwiw), it lists mods and plugins separately. It actually sounds more like you're unfamiliar with Vortex than any actual real criticism in this or your prior post. ![]() I'm not saying it is bad and I do use it for other games which it does very well but I find NMM worked, still works and will continue to work so why break it If Vortex does the same, then I uninstall, reinstall still the same so I have to Bash or NMM to activate. There are comments that it doesn't activate ESL's but you click the tab and instantly activate and deactivate any mod. Originally posted by Sauro:I've been using the community version of NMM for all of my current 200 hours of Fallout 4 and it has not had a single issue thus far.
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Gain of function mutant p53 p53 network p53 reactivation tumorigenesis. But similar to bone marrow transplant from a parent, the immune restoration was incomplete. It results from a mutation in the IL-2 receptor gamma gene ( IL-2RG ). Early results from trials of gene therapy for X-SCID resulted in life-saving correction of T lymphocytes. Not only will this strategy abrogate mutant p53 GOF, but it will also restore WT p53 tumor-suppressive functions. An engineered virus brings a healthy copy of the gene into the stem cells to replace the mutated gene that causes the disease. Thus, we suggest that targeting mutant p53, via its reactivation to the wild-type form, may serve as a promising therapeutic strategy for many cancers that harbor mutant p53. Finally, we discuss mechanisms by which "Mother Nature" tries to abrogate the pro-oncogenic functions of mutant p53. Because of a gene mutation, babies who are born with X-linked severe combined immunodeficiency (X-SCID) do not develop immune cells properly, leaving them highly susceptible to infections. It is one of the most serious primary immunodeficiency disorders with early death due to disturbed or absent T and B cell functions. In the current review, we discuss the various GOF effects of mutant p53, and how it may serve as a central node in a network of genes and proteins, which, altogether, promote the tumorigenic process. Severe combined immunodeficiency disease (SCID) is an inherited primary immunodeficiency disorder that presents by six months of age with opportunistic infections caused by bacteria, viruses, fungi, and protozoa. Over time, they may develop: recurrent or severe. Infants with SCID usually appear healthy at birth. These genes encode three proteins that are components of a multimeric transcriptional complex, RFX, which binds a sequence named an X box, present in the promoter of all MHC. The genes mutated in Groups B, C, and D are named RFXANK, RFX5, and RFXAP. ![]() ![]() A growing body of evidence suggests that these pro-oncogenic functions of mutant p53 proteins are mediated by affecting the transcription of various genes, as well as by protein-protein interactions with transcription factors and other effectors. Severe combined immunodeficiency (SCID) is a group of inherited genetic disorders characterized by a profound deficiency in cellular and humoral immunity arising from one of many T-cell maturation defects in the bone marrow or thymus gland. One of these, named the MHC class II transactivator, or CIITA, is the gene mutated in Group A. Aside from losing the tumor-suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent, novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function (GOF). The p53 protein is mutated in about 50% of human cancers. ![]() Edit object: new functions to set / get caret position. Maximum number of objects (in Frame properties) is now 30000. Note: this is limited to the Windows runtime only for the moment, the other platforms still use 32 channels. You can now use up to 48 sound channels. Debugger: the Add Object button is no longer grayed when you click on Rewind or Play. This allows to use the Android OBB extension more efficiently. Build: in Android apps the ACE's used in frames that have the "Don't include at build time" option are now included in the APK, and the images and sounds used in those frames are no longer included in the APK. Effect List dialog box: incorrectly closes when you double-click an expand button. Data Elements editor: multiple selection in Sounds tab to allow you to export all sounds at once. Global Events: pathnames of external files were not automatically updated when you move a MFA to another folder. Global Events: when you rename an object and this was the last object with this name in the application, the object is renamed in the global events. Global Events / Behavior editor: object list empty when you add a Create action (or others) and a search string was previously set in the object list dialog box. Global events / behaviors: when you paste events copied from a behavior, the icon of object that owns the behavior was messing up the object list. Global events / behaviors: when you paste events that contain objects that are not already used in the global events or behavior you are editing, the program now imports them directly instead of displaying "bug" objects. Global events / behavior editor: object order and folders are now saved. Global events / behavior editor: Undo is now available after running the application. Global events / behavior editor: faster to open in big applications. Event list editor: crashes could happen when dropping an action to an Insert New Action line. Event list editor: crashes could happen when editing actions in the main events when the object bar contains object shortcuts. Event list editor: crashes could happen when going to a line in a closed group. Event editor: folder corruption caused by old versions is automatically fixed when you open a frame (if the folder were corrupted, this might change a bit the way your objects are organized). Event editor: when you clone an object that is in a closed folder the object was displayed outside the folder although it was inside. Event editor: when you double-click the closing bracket of a folder that contains a selected object, the selection was not cleared. Event editor: holding CTRL while mouse wheel scrolling scrolls horizontally. Path Movement editor: memory corruption when nodes are named and new nodes are inserted. Frame / Event editors: incorrect selection in the Frame dropdown list in the Navigate toolbar. Frame editor: you can now drag multiple items from the frame to a folder in the object window. Frame editor: automatic scrolling when dragging object to the top of bottom of the object window. Frame Editor: "ghost" objects are automatically removed when the MFA is loaded. Frame Editor: now faster to open frames with lots of objects. Frame Editor: drag & drop of lots of objects from a frame to another one, or pasting lot of objects, is faster. Frame Editor: refresh of object window is faster. General: new Global Event editor button in toolbar. General: recent files list size increased to 12 filenames. General: Open/Save Project have been moved to a Project sub-menu. Please read the change log for the changes in the Android runtime, which now uses Gradle instead of Ant. Due to the numerous changes that have been made, and even if this build has been tested a lot by the testers of 2.5+, be careful and make backup copies of the MFA files you edit with this version. Sorry for the delay for this update, we've been extremely busy and releasing an update in the middle of the changes we were making was not easy. Real-time presentation of shadows, borders, textures, spatiality, and much more Unlimited recovery steps for simple experimentationįlexible control of color and texture in all areas of the image It's just as easy to position spatial shadows and their colors, blurs, and transparency. Three freely positionable light sources enable you to intuitively specify the direction and color of light on your 3D object with the mouse. You can keep track of the bigger picture despite tricky twists and turns. In order to avoid being distracted by fill colors and textures, you can also display texts and objects in a lattice model. color, edge style, font, texture, animation style, line spacing and print tracking – for the complete text or separately for selected areas or characters. You can custom format them just as you would with conventional word processing programs.Īll attributes can be designed just as quickly and easily, e.g. And change the speed of movement for any direction as well.Įnter your text directly and choose from a range of fonts including those already on your computer. For example, your title appears in the background and then flies towards the viewer and disappears off to the right.įreely move 3D objects in any direction. In order to avoid being distracted by fill colors and textures, you can also display texts and objects as a lattice model.Īnimate how the same object fades in and out separately from each other. turns, rotations, fades in and out, pulses, swings).Ĭomplement word processing & presentation programsĮxport as screensavers, icons, and much more Specify the spatial depth and perspective of your 3D graphics easily and in real time simply by dragging with the mouse or by rotating the object freely on its axes.įully automatically bring complete areas of text, individual characters, or selected objects to life (e.g. Makes shapes look, for example, as if they were chiseled out of stone. Use MAGIX 3D Maker 7 with your own texts, included form templates, or freely importable graphics to create impressive 3D titles, objects, and animationsĬhoose from over 700 templates, more than 400 textures and 33 different edge styles. A number of designs and templates in different styles, plus intuitive real-time editing and easy-to-understand tools will help you to quickly produce professional results. MAGIX 3D Maker 7 transforms any texts or shapes into high-quality 3D graphics and animations. 3D for logos, websites, videos and much more ![]() digitalWrite() and the other pin-manipulation functions do all that for you, so you usually don't need to know which pin is on which port. That notation is ubiquitous for referring to pins in normal AVR programming (as in, without using the IDE) because then you have no pin numbers - just port registers with 8 bits each, so you want to set the output state of PA3, you have to do PORTA|=(1<<3) or PORTA&=~(1<<3) - and if you have interrupts touching those registers, you also need to turn off interrupts to prevent an interrupt from changing the value of the register between when you read it to |= it and when you store the value to the register and restore the status register afterwards. ![]() This is the kind of thing I used some years ago (with other hardware) to build a hardware-in-the-loop simulator of a Cessna Skymaster. Unofficial Mega2560 pinout diagram (and official photo) 4: Mega2560: ATmega16U2 chip USB-to-TTL and UART IN PROGRESS Slides in this section IBD: Arduino. The PCB uses an ATMega16U2 and ATMega2560 just like the proper Arduino Mega does. It is available in a 100-pin Quad Flat Package. I have just finished designing and assembling the first custom PCB. Arduino Mega is based on ATmega2560 Microcontroller, an 8-bit AVR Architecture based MCU from ATMEL. Arduino Board Pinout Diagrams: Due, Esplora, Leonardo, Mega, Micro, Mini. With the Arduino Mega 2560, you can run the code in 'external mode' where the model running in the Mega can be monitored and controlled from the Simulink visual interface. Hi all, I am working on a project based around the Arduino Mega2560. I didn't know that the Arduino IDE would allow you to use the "PXN" notation where X is the port and N is the bit number to reference pins - I didn't think those constants were defined, but if it compiles using those, they must be defined they may even be defined the way you think they are. The Wiring platform consisted of a printed circuit board (PCB) with an ATmega128. Arduino UNO R3 pin diagram shows that it has 6 analog inputs, 14 digital input/output pins (of which 6 can be used as PWM outputs), a 16 MHz ceramic crystal resonator, a USB-B port, an ICSP header, Atmega328p and Atmega 16U2 processor, a power jack and, a reset button. Arduino Mega Pinout Voltage Regulator-The voltage regulator converts the input voltage to 5V. It has a crystal oscillator-16 MHz, a power jack, an ICSP header, a USB-B port, and a RESET button. Pins PA0~PA7 are arranged consecutively on the Mega's pin mapping, and are digital pins 22 through 29. Quale la denominazione dei pin del connettore ICSP dellATMEGA16AU dellArduino Leonardo Dove sono le porte seriali dellArduino MEGA2560 Se conoscete a. Arduino Mega 2560 has 54 digital input/output pins, where 16 pins are analog inputs, 14 are PWM pins, and 6 are hardware serial ports (UARTs). ![]() Mc uses a JSON formatted configuration file used for storingĬertain kinds of information, such as the aliases forįor Linux and OSX, the default configuration file location isįor Windows, mc attempts to construct a default file path by trying For S3 services, use mc event add to configureīucket event notifications on S3-compatible services. The mc watch command watches for events on the specified MinIO bucket or The mc version commands enable, disable, and retrieve the versioning status for a MinIO bucket. The mc pipe command streams content from STDIN to a target object. The mc ping command performs a liveness check on a specified target. The command outputs the time it took to upload the file. The mc od command copies a local file to a remote location in a specified number of parts and part sizes. Mc mv also supports moving objects between a local filesystem and MinIO. The mc mv command moves an object from source to the target, such asīetween MinIO deployments or between buckets on the same MinIO deployment. Mc mirror supports filesystems, MinIO deployments, and other S3-compatible hosts as the synchronization source. The mc mirror command synchronizes content to MinIO deployment, similar to the rsync utility. The mc mb command creates a new bucket or directory at the ![]() The mc ls command lists buckets and objects on MinIO or another Use the commands to register a deployment, unregister a deployment, display information about the cluster’s current license, or update the license key for a cluster. The mc license commands work with cluster registration for MinIO SUBNET. ![]() As long as you have version 1.2.00 or later, LightBurn should be ready to use. After downloading the DMG file, open the file (typically by double-clicking) and drag LightBurn into your Applications folder. Installing LightBurn on Mac is accomplished the same way as most Mac software. That's it! Locate the LightBurn icon to launch the program If you update the software later, you do not need to repeat this step. If you have never installed LightBurn before, you might need to check the 'Install FTDI driver' button - this is mostly used by DSP controllers, like Ruida and TopWisdom, and it only needs to be done once. Windows may ask if you trust us first.Ĭlick Next, then click 'Install'. Launch the installer by double-clicking it. As with most things, a faster computer will make it easier to work with large images or complex vector graphics. LightBurn does not require a powerful computer for most work, though if your designs contain a lot of images, more memory is helpful. Ubuntu users unable to upgrade beyond Ubuntu 18.04 should download version 1.2.01 instead of the current version. LightBurn will run on Windows 7.0 or later (32 or 64 bit), MacOS 10.11 or later, or 64 bit Linux (Ubuntu 20.04 or Fedora 36, anything else may not work as intended). On Windows and Mac you can just double-click the downloaded file. When you've completed the download, you should see the file in your "Downloads" folder. Windows 32-bit - some older systems might need this. ![]() Windows 64-bit - nearly all modern computers are 64 bit.Download the version that matches your computer. ![]() You'll see links for the current release of LightBurn. The first step is to go to Īt the top, click "Download and Trial" (or click here) Beginner Docs Downloading & Installing LightBurn ¶ Downloading LightBurn ¶ ![]() And if you still have questions, please contact us ! We love solving unique tape challenges.In this comprehensive guide to all things double-sided tape, we’re giving you all the information you need to know about choosing and using double-sided tape in seaming, splicing, bonding and beyond. As labor shortage becomes a big issue, finding ways to save installation time is becoming critical.įor more information on double-coated adhesive tapes, please visit The Complete Technical Guide to Double-Sided Tape. Our double-coated carpet tape features an aggressive adhesive system that’s perfect for carpet hold-down but will leave no residue once removed.Įasy installation of building materials. More and more manufacturers are making their products with double-sided tape for easy installation. Often you need to cover floors or walkways with carpets or floorboards to protect the surface while construction is underway. Examples include light switch junction boxes electrical panels electronic thermostats baseboards and crown moldings.įloor protection. Temporary double-sided tape is the perfect solution to hold something in place while you permanently mount it. Temporarily mount something prior to permanently fastening. Use double-sided insulation tape to attach insulation to the building and ensure it sticks. Use double-sided tape for any flooring underlayment including sound attenuation materials. With more buildings becoming airtight, sound is becoming a big issue. Overlap any flooring underlayment including sound attenuation barriers. You can also use a high-performance double-sided vapor barrier tape to attach the barrier to the walls instead of using screws. More and more builders are putting vapor barriers down in crawlspaces to seam the building envelope as even in the basement there is air leakage. Overlap vapor barrier seams and attach them to cement walls in crawlspaces. Using a roller to bond the tape may help, but the better solution is to use double-sided tape as a housewrap tape so you can overlap seams and ensure no water gets through. Here’s the deal: single-sided tape used to seal housewrap may allow water to migrate behind the tape, and ultimately into the structure. Here are just some of the construction applications where double-sided tape plays a major role and we expect more and more in the future. As more and more builders start to focus on seaming the building envelope and getting improved HERS scores, tape is fast becoming a way to get the job done well. That said, we are thrilled to see more and more tape being used in construction applications, especially since adhesive technology has come a long way. For more on this, check out our infographic, The Secret to Choosing the Right Tape. ![]() Ice, rain, humidity, heat, UV, and dirt are all factors to consider when choosing the right tape or, more importantly, preventing tape failure. A product that you used in spring or summer might not work in sub-zero winter. Outside of materials, it’s also important to understand the field conditions. Concrete with a textured surface is going to require more adhesive strength than, say, carpet padding.īest Uses for Double-Sided Tape in Construction Whether you’re bonding glass, wood, steel, concrete, foam, and/or plastic together, it’s important to understand the materials you are bonding. Sounds great, right!? Yet, much like everything else on the job site, choosing the right double-sided tape for the specific application is not as easy as it sounds. Designed to stick two surfaces together without being seen, these versatile tapes deliver neater-looking projects and better craftsmanship. And unlike screws or rivets – which join materials at a single point – high-strength double-sided tape permanently adheres one substrate to another while spreading the stress load. ![]() Double-sided tape is any tape that is coated with adhesive on both sides. Once the returned item is received, a gift certificate will be mailed to you. If the item was marked as a gift when purchased and shipped directly to you, you’ll receive a gift credit for the value of your return. If you need to exchange it for the same item, send us an email at and send your item to: 17 Burns Rd, Heathcote NSW 2233, Australia. We only replace items if they are defective or damaged. Only regular priced items may be refunded, unfortunately sale items cannot be refunded. ![]() If you’ve done all of this and you still have not received your refund yet, please contact us at items (if applicable) There is often some processing time before a refund is posted. Then contact your credit card company, it may take some time before your refund is officially posted. If you haven’t received a refund yet, first check your bank account again. If you are approved, then your refund will be processed, and a credit will automatically be applied to your credit card or original method of payment, within a certain amount of days. We will also notify you of the approval or rejection of your refund. Once your return is received and inspected, we will send you an email to notify you that we have received your returned item. call us on 1300 767 443 or email at item not in its original condition is damaged or missing parts for reasons not due to our error will not cover in refund policy.Īny item that is returned more than 30 days after delivery will not accept refund request. Please do not send your purchase back to the manufacturer. To complete your return, we require a receipt or proof of purchase. It must also be in the original packaging. To be eligible for a return, your item must be unused and in the same condition that you received it. If 30 days have gone by since your purchase, unfortunately, we can’t offer you a refund or exchange. Would it be possible to lose pressure on that end of the pump causing the cycling? If so, I would have expected it to continually cycle after shutting the valve after the pump.Our policy lasts 30 days. Should a check valve be added between the pump and the tank. After taking the valves out and hooking the pump back up to the tanks, water flowed into the pump through the valve and I did not have to prime it. I still had to prime the pump by pouring water in it even though the water should have been flowing from the tank. One interesting thing, when I originally hooked the tank up to the pump no water came through intake valve on the pump. We do not have a check valve from the tank or after the pump. we shut the water off after the pump and it eliminates the cycling which leads me to think that there is a small leak somewhere. Can anyone offer any help? A few other things. I have seen that on this forum as well, but cannot find info anywhere on the web or in the manual how to actually do that. The manual also says to check the internal pressure of the pump and make sure it is set at 70% of the outflow pressure. We also took the valves out of the pump to make sure there were no debris keeping the valve open. We have been going through the house shutting off valves to fixtures to pin point a leaking fixture that may be causing the issue but have not found one. Now, the pump has been cycling every 3-4 minutes when water is not being used and eventually leads to a leak in the system warning light. After hooking the pump up it worked for 2 days without any issue. However, the father in law wanted to go with that pump and here we are. I did quite a bit of research prior and saw that the Scala 2 pump had mixed reviews. The scala 2 pump receives water from the bottom of the tanks and feeds the rest of the house including boiler. We just installed two 300 gallon tanks in the basement which are filled from the well with a large pressure tank (previously had that) at a rate of 1/2 gallon a minute. They have a low capacity/low recharge well they have been dealing with for 20+ years. New to the site but found some good info on here for a project I helped my father in law with last weekend. ![]() Two weeks ago, in a courtroom in Allegheny County, Pa., Mancuso pleaded guilty as charged. But she issued a statement to ABC News, which said: "The unearthing of this horrific experience has further strengthened our resolve to advocate for policy and law enforcement tools to help prevent applicants with criminal motives from becoming adoptive parents in the future." Jeannene Smith, the woman who arranged the adoption, refused to discuss the adoption, citing constraints in New Jersey law. They are motivated by desiring to help children have families." But Atwood said typically, "people do not provide adoption service for money. Mancuso paid tens of thousands of dollars for his adoption of Masha. And while more than $500 million has been spent on Russian adoptions since the fall of the Soviet Union, Flatley said, "The policy seems to be, if the check clears, the kid is yours." While post-placement supervision is required in Pennsylvania for domestic adoptions from foster care, no such law exists for international placement. Just one, they say should have turned up some disturbing details - like the fact that Masha had no bedroom. "Something went wrong, clearly." Adoption experts are especially troubled by the fact that, according to Masha, there were no home visits when she got to Pittsburgh. Tom Atwood, president of the National Council on Adoption, says he saw the study that was performed on Mancuso, and said it was "fairly typical." But he adds that Masha's adoption is not defensible. She has also been hired by Masha's lawyer to find out how a pedophile could have adopted a young child. "It doesn't appear that they talked to anybody about Mancuso, that they simply took what Mancuso said to them at face value and placed this child with him," said Maureen Flatley, a lobbyist who specializes in adoption and child welfare. Mancuso is very capable, willing and well-prepared to provide a stable and loving home." Instead, Mancuso's agency relied on a home study prepared by a Pittsburgh social worker. I feel somehow responsible," Rachelle said.īut McDade and her daughter both say they were never contacted by adoption authorities. When I first found out that he adopted a little girl I should have spoke up, I should have said something. He had molested Rachelle as a child, they said. His ex-wife, Doreen McDade, and his 28-year-old daughter, Rachelle, told ABC News he had done this before. It turns out Masha was not Mancuso's first victim. "I guess I'd still be waiting, like I did for five years," she said. She says she doesn't know what she would have done if they didn't come. Masha was finally rescued at the age of 10. So once I said something - I said everything else. "It was like, I finally had someone to talk to. Holtz remembers her asking: "Is this about my secret?" An agent had taken Mancuso inside his house, but even there, he tried to keep Masha from talking by yelling out to her.īut Masha spoke anyway. The agents found computer disks with child pornography - but the biggest discovery was to come from Masha herself. "He wasn't happy that we were there and it was obvious to us," he said. They immediately separated them, and Clinton says he could tell Mancuso was concerned. When they pulled up, they saw Mancuso and Masha outside. On May 27, 2003, federal agents Denise Holtz and Tom Clinton visited Mancuso's home, looking for the photos advertised on the Internet. Zaglifa pretended to want them too, and struck up a conversation with someone using the handle "NkdSister." After chatting with him for a bit, he had a gut feeling - and traced NkdSister's Internet address to Pittsburgh. There is a limited supply of child porn, and so pedophiles are always looking for arousing new images - so when Masha's fresh pictures appeared, this caused a feeding frenzy. Mike Zaglifa had been posing as a pedophile on the Internet, where obscene pictures of children are often traded like baseball cards. The road to Masha's rescue began hundreds of miles away in the Chicago suburb of Palos Heights. So I just didn't tell anybody, 'cause I was afraid." "He wouldn't tell me what it would be, but he'd just say something bad would happen. ![]() "He'd tell me not to tell anyone, or else something bad would happen," Masha said. To keep her silent he used rewards - as well as threats. "But it always came back to me - couldn't stop it." "I'd make myself think of other things when it was happening," she said. |
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